Take into account alternant therapies that are not reasonable CYP3A inducers throughout remedy with mitapivat. If struggling to prevent coadministration, watch Hb and titrate outside of 50 mg BID, if required, but don't exceed mitapivat dose of one hundred mg BID. .pentobarbital raises effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabo